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2. DENDRITIC SPINE MORPHOGENESIS
2.1. STRUCTURE OF DENDRITIC SPINES
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2.2. DENDRITIC SPINE DEVELOPMENT
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Fig 6. Structure of dendritic filopodia and spines, and a model of an asymmetric synapse. (A) Filopodia are the precursors of dendritic spines, and they develop into three types of dendritic spines: thin type, stubby type and mushroom type spines. Gray disks: PSD structure and red circles: F-actin.
(B) The synapse is formed between the presynaptic terminal and the dendritic spine. Synaptic vesicles are found in the presynaptic terminal. Two structural elements: actin cytoskeleton and PSD are important for the function of the dendritic spine. PSD contains the neurotransmitter receptors.
Actin-binding proteins, including drebrin, are stabilizing the dendritic spine architecture. Modified from Sekino et al, 2007.
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