• Ei tuloksia

The strength of this study in comparison to others is that it is a recent study and covers most of the recent research in seizure detection using data mining methods, Also, the time frame covers the most recent methods and techniques used for seizure detection. Some of the limitations encountered include, the number of studies that was gotten for the analysis, a good way to overcome this limitation will be to include other databases to see if more studies could be gotten. Also, some of the research articles were not accessible due to the need to subscribe to the journal site as they were on the subscribed list by the university and all efforts to get the full text proved abortive. Lastly, there was a huge number of diverse data mining classification algorithms or methods which requires extensive research and finally conducting a scoping review as a pair helps to give the study credibility and avoidance of selection bias, but as this is a masters thesis it was conducted by an individual.

53 7.3 Conclusion

In conclusion, data mining has found its use in a wide variety of areas which includes insurance, business and healthcare. In healthcare, it has found use in pattern recognition and in its ability to extract previously unknown information, which is why it became an interest area for research in epilepsy seizure detection. The manual process of analyzing EEG data has been a problem area in seizure detection because of the time and the differences in what constitutes a spike between neurophysiologists. This has prompted the use of data mining methods in the automatic detection of epilepsy to help solve this conundrum.

Overall, data mining could help neurophysiologists and physicians make vital decisions which in turn lead to better health outcome for people suffering from epilepsy This study identifies the use of EEG data in the literature as those aimed at seizure detection and at comparing the performances of the different data mining methods, also the different data mining methods used in seizure detection were highlighted and the data mining methods which can provide valuable information to physicians that can then be used in clinical decision support were identified. The findings of this study suggest data mining methods can be effective in seizure detection, several of the methods provided an accuracy or sensitivity level which shows these methods could be of immense benefit when applied in the clinical environment.

In the future there might be a need to develop a universal method which is fast, accurate, interpretable, cost-effective and accepted as the primary method in EEG seizure detection using data mining methods.

54 8 REFERENCES

Abualsaud, Khalid, Massudi Mahmuddin, Mohammad Saleh, & Amr Mohamed 2014.

Performance Comparison of classification algorithms for EEG-based remote epileptic seizure detection in Wireless Sensor Networks. In Computer Systems and Applications (AICCSA), 2014 IEEE/ACS 11th International Conference on (pp. 633-639). IEEE.

Adeli, Hojjat, Ziqin Zhou, & Nahid Dadmehr, 2003. Analysis of EEG records in an epileptic patient using wavelet transform. Journal of neuroscience methods, 123(1), pp.69-87.

Adam, Bao-Ling, Yinsheng Qu, John W. Davis, Michael D. Ward, Mary Ann Clements, Lisa H. Cazares, & O. John Semmes 2002. Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. Cancer research, 62(13), pp.3609-3614.

Andrzejak, Ralph G., Klaus Lehnertz, Florian Mormann, Christoph Rieke, Peter David,

& Christian E. Elger 2001. Indications of nonlinear deterministic and finite-dimensional structures in time series of brain electrical activity: Dependence on recording region and brain state. Physical Review E, 64(6), p.061907.

Anderson, Stuart, Pauline Allen, Stephen Peckham, & Nick Goodwin 2008. Asking the right questions: scoping studies in the commissioning of research on the organisation and delivery of health services. Health research policy and systems, 6(1), p.7.

Aguiar-Pulido, Vanessa, Jose A Seoane, Marcos Gestal, & Julián Dorado 2013. Exploring patterns of epigenetic information with data mining techniques. Current pharmaceutical design, 19(4), pp.779-789.

Ahmed, Laeeq, Ake Edlund, Erwin Laure, & Stephen Whitmarsh 2016. Parallel Real Time Seizure Detection in Large EEG Data. In International Conference on Internet of Things and Big Data, IoTBD 2016, Rome, Italy, 23 April 2016 through 25 April 2016 (pp.

214-222). SciTePress.

Alkan, Ahmet, Etem Koklukaya, & Abdulhamit Subasi 2005. Automatic seizure

55

detection in EEG using logistic regression and artificial neural network. Journal of Neuroscience Methods, 148(2), pp.167-176.

Arida, Ricardo M., Carla A. Scorza, Beny Schmidt, Marly de Albuquerque, Esper A.

Cavalheiro, & Fulvio A. Scorza 2008. Physical activity in sudden unexpected death in epilepsy: much more than a simple sport. Neuroscience bulletin, 24(6), pp.374-380.

Arksey, Hilary, & Lisa O'Malley 2005. Scoping studies: towards a methodological framework. International journal of social research methodology, 8(1), pp.19-32.

Banerjee, Poonam Nina, David Filippi, & W. Allen Hauser 2009. The descriptive epidemiology of epilepsy—a review. Epilepsy research, 85(1), pp.31-45.

Bell, G. S., & J. W. Sander 2001. CPD—Education and self-assessment the epidemiology of epilepsy: The size of the problem. Seizure, 10(4), pp.306-316

Bellazzi, Riccardo, & Blaz Zupan 2008. Predictive data mining in clinical medicine:

current issues and guidelines. International journal of medical informatics, 77(2), pp.81-97.

Chaovalitwongse, W., P. M. Pardalos, L. D. Iasemidis, W. Suharitdamrong, D-S. Shiau, L. K. Dance, O. A. Prokopyev, V. L. Boginski, P. R. Carney, & J. C. Sackellares 2007.

Data mining in EEG: Application to epileptic brain disorders. In Data Mining in Biomedicine (pp. 459-481). Springer, Boston, MA.

Chen, Lu-Yen A., & Tonks N. Fawcett 2016. Using Data Mining Strategies in Clinical Decision Making: A Literature Review. CIN: Computers, Informatics, Nursing, 34(10), pp.448-454.

Bian, Jiang, Umit Topaloglu, & Fan Yu 2012. Towards large-scale twitter mining for drug-related adverse events. In Proceedings of the 2012 international workshop on Smart health and wellbeing (pp. 25-32). ACM.

56

Brachman, Ronald J., & Tej Anand 1994. The Process of Knowledge Discovery in A First Sketch. AAAI Tech. Rep. WS-94-03.

Brodie, M. J., S. D. Shorvon, R. Canger, P. Halasz, S. Johannessen, P. Thompson, H. G.

Wieser, & P. Wolf 1997. Commission on European Affairs: appropriate standards of epilepsy care across Europe. Epilepsia, 38(11), pp.1245-1250.

Buczak, Anna L., & Erhan Guven 2016. ‘A Survey of Data Mining and Machine Learning Methods for Cyber Security Intrusion Detection’, IEEE COMMUNICATIONS SURVEYS

& TUTORIALS, 18(2). doi: 10.1109/COMST.2015.2494502.

Burghard, C. 2012. Big data and analytics key to accountable care success. IDC Health Insights, pp.1-9.

Clancy, T.R. &Gelinas, L., 2016. Knowledge Discovery and Data Mining: Implications for Nurse Leaders. Journal of Nursing Administration, 46(9), pp.422-424.

Codd, E. F. 1993. Providing OLAP (On-Line Analyti-cal Processing) to User-Analysts:

An IT Mandate. E. F. Codd and Associates

Codd, Edgar F., Sharon B. Codd, & Clynch T. Salley 1993. Providing OLAP (on-line analytical processing) to user-analysts: An IT mandate. Codd and Date, 32.

Coiera, Enrico 2015 ‘Guide to Health Informatics. CRC press. p. 440. doi: 10.1007/978-3-319-17662-8.

Chaovalitwongse, W., P. M. Pardalos, L. D. Iasemidis, W. Suharitdamrong, D-S. Shiau, L. K. Dance, O. A. Prokopyev, V. L. Boginski, P. R. Carney, & J. C. Sackellares 2007.

Data mining in EEG: Application to epileptic brain disorders. In Data Mining in Biomedicine (pp. 459-481). Springer, Boston, MA.

Czajkowski, Marcin, Marek Grześ, & Marek Kretowski 2014. Multi-test decision tree and its application to microarray data classification. Artificial Intelligence in Medicine.

doi: 10.1016/j.artmed.2014.01.005.

57

Eastwood, Elizabeth A., Jay Magaziner, Jason Wang, Stacey B. Silberzweig, Edward L.

Hannan, Elton Strauss, & Albert L. Siu 2002. Patients with hip fracture: subgroups and their outcomes. Journal of the American Geriatrics Society, 50(7), pp.1240-1249

Echauz, Javier, Stephen Wong, Otis Smart, Andrew Gardner, Gregory Worrell, & Brian Litt 2008. Computation applied to clinical epilepsy and antiepileptic devices. In Computational neuroscience in epilepsy (pp. 530-558).

Ehrich, Kathryn, George K. Freeman, Sally C. Richards, Ian C. Robinson, & Sasha Shepperd 2002. How to do a scoping exercise: continuity of care. Research, Policy and Planning, 20(1), pp.25-29.

Elferink, Jan GR 1999. Epilepsy and its treatment in the ancient cultures of America.

Epilepsia. ;40:1041–1046.

Fayyad, Usama, Gregory Piatetsky-Shapiro, & Padhraic Smyth 1996 .From data mining to knowledge discovery in databases’, AI magazine, pp. 37–54. doi:

10.1145/240455.240463.

Fernandes, Lorraine M., Michele O'Connor, & Victoria Weaver 2012. Big data, bigger outcomes. Journal of AHIMA, 83(10), pp.38-43.

Feldman, Susan, Judy Hanover, Cynthia Burghard, & David Schubmehl 2012. Unlocking the power of unstructured data. IDC Health Insights,# HI235064, pp.1-10.

Finlay, Steven 2014. Predictive analytics, data mining and big data: Myths, misconceptions and methods. Springer.

Fisher, R.S., Cross, J.H., D'souza, C., French, J.A., Haut, S.R., Higurashi, N., Hirsch, E., Jansen, F.E., Lagae, L., Moshé, S.L. & Peltola, J., 2017. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia, 58(4), pp.531-542.

58

Flexer, Arthur 2000. Data mining and electroencephalography. Statistical Methods in Medical Research, 9(4), pp.395-413.

Frost, Sullivan 2012. Drowning in big data? reducing information technology

complexities and costs for healthcare organizations.

http://www.emc.com/collateral/analyst-reports/frost-sullivan-reducing-information-technology-complexities-ar.pdf.available accessed 16.4.2018

Fu, Tak-chung 2011. A review on time series data mining. Engineering Applications of Artificial Intelligence, 24(1), pp.164-181.

Grant, Maria J., & Andrew Booth 2009. A typology of reviews: an analysis of 14 review types and associated methodologies. Health Information & Libraries Journal, 26(2), pp.91-108.

Gotman, Jean 1999. Automatic detection of seizures and spikes. Journal of Clinical Neurophysiology, 16(2), pp.130-140.

Gupta, Deepa, Sangita Khare, & Ashish Aggarwal 2016, April. A method to predict diagnostic codes for chronic diseases using machine learning techniques. In Computing, Communication and Automation (ICCCA), 2016 International Conference on (pp. 281-287). IEEE.

Guruvayur, Sivaramakrishnan R., & R. Suchithra2017, May. A detailed study on machine learning techniques for data mining. In Trends in Electronics and Informatics (ICEI), 2017 International Conference on (pp. 1187-1192). IEEE.

Han, Jiawei, Micheline Kamber, & Jian Pei 2006. Mining frequent patterns, associations, and correlations. Data Mining: Concepts and Techniques (2nd ed., pp. 227-283). San Francisco, USA: Morgan Kaufmann Publishers.

Harper, Paul R 2005. A review and comparison of classification algorithms for medical decision making. Health Policy, 71(3), pp.315-331.

59

Hand, D.J., Mannila, H. & Smyth, P., 2001. Principles of data mining. MIT press.

Huang, Hongli, Hao Zhou, & Nuan Wang 2015. Recent advances in epilepsy management. Cell biochemistry and biophysics, 73(1), pp.7-10.

Haydari, Zainab, Yanqing Zhang, & Hamid Soltanian-Zadeh 2011, November. Semi-automatic epilepsy spike detection from EEG signal using genetic algorithm and wavelet transform. In Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on (pp. 635-638). IEEE.

Joudaki, Hossein, Arash Rashidian, Behrouz Minaei-Bidgoli, Mahmood Mahmoodi, Bijan Geraili, Mahdi Nasiri, & Mohammad Arab 2014. Using data mining to detect health care fraud and abuse: a review of literature. Global journal of health science. Canadian Center of Science and Education, 7(1), pp. 194–202. doi: 10.5539/gjhs.v7n1p194.

Kantardzic, Mehmed 2011. Data Mining: Concepts, Models, Methods, and Algorithms’, in Wiley-IEEE Press, p. 552. doi: 10.1002/9781118029145.

Kruse, Clemens Scott, Rishi Goswamy, Yesha Raval, & Sarah Marawi 2016. Challenges and opportunities of big data in health care: a systematic review. JMIR medical informatics, 4(4).

Larose, Daniel T., & Chantal D. Larose 2015. Data mining and predictive analytics. John Wiley & Sons.

Iasemidis, Leonidas D., Deng-Shan Shiau, Wanpracha Chaovalitwongse, J. Chris Sackellares, Panos M. Pardalos, Jose C. Principe, Paul R. Carney, Awadhesh Prasad, Balaji Veeramani, & Kostas Tsakalis 2003. Adaptive epileptic seizure prediction system.

IEEE transactions on biomedical engineering, 50(5), pp.616-627.

Lehnertz, Klaus, & Brian Litt 2005. The first international collaborative workshop on seizure prediction: summary and data description. Clinical neurophysiology, 116(3), pp.493-505.

60

Rokach, Lior, & Oded Maimon 2005. Introduction to knowledge discovery in database.

Data Mining and Knowledge Discovery Handbook, pp. 1–17. doi: 10.1007/0-387-25465-X_1.

Martinez-del-Rincon, Jesus, Maria J. Santofimia, Xavier del Toro, Jesus Barba, Francisca Romero, Patricia Navas, & Juan C. Lopez. Non-linear classifiers applied to EEG analysis for epilepsy seizure detection’, Expert Systems with Applications. doi:

10.1016/j.eswa.2017.05.052.

Mbuba, Caroline K., Anthony K. Ngugi, Charles R. Newton, & Julie A. Carter 2008. The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies. Epilepsia, 49(9), pp.1491-1503.

McGrogan, Nick, 1999. Neural network detection of epileptic seizures in the electroencephalogram.

Meinardi, H., R. A. Scott, R. Reis & On Behalf Of The Ilae Commission on the Developing World, J.S., 2001. The treatment gap in epilepsy: the current situation and ways forward. Epilepsia, 42(1), pp.136-149.

Mitchell, Tom M 1997. Machine learning, ser. Computer Science Series. Singapure:

McGraw-Hill Companies, Inc.

Mohamed, Abduljalil, Khaled Bashir Shaban, & Amr Mohamed 2012. Evidence Theory-Based Approach for Epileptic Seizure Detection Using EEG Signals. in 2012 IEEE 12th International Conference on Data Mining Workshops. doi: 10.1109/ICDMW.2012.36.

Mohseni, Hamid R., A. Maghsoudi, & Mohammad B. Shamsollahi 2006. Seizure detection in EEG signals: A comparison of different approaches. In Engineering in Medicine and Biology Society, 2006. EMBS'06. 28th Annual International Conference of the IEEE (pp. 6724-6727). IEEE.

61

Mporas, Iosif, Vasiliki Tsirka, Evangelia I. Zacharaki, Michalis Koutroumanidis, &

Vasileios Megalooikonomou 2014. Online seizure detection from EEG and ECG signals for monitoring of epileptic patients. In Hellenic Conference on Artificial Intelligence (pp.

442-447). Springer, Cham.

Nelson, Ramona, & Nancy Staggers 2016. Health Informatics-E-Book: An Interprofessional Approach. Elsevier Health Sciences.

Niedermeyer, Ernst, & FH Lopes da Silva 2005. Electroencephalography: basic principles, clinical applications, and related fields. Lippincott Williams & Wilkins.

Nikam, Sagar S 2015. A comparative study of classification techniques in data mining algorithms. Oriental Journal of Computer Science & Technology, 8(1), pp.13-19.

Oğulata, Seyfettin Noyan, Cenk Şahin, & Rızvan Erol 2009. Neural network-based computer-aided diagnosis in classification of primary generalized epilepsy by EEG signals. Journal of medical systems, 33(2), pp.107-112.

Peters, Micah, Christina Godfrey, Patricia McInerney, Cassia Soares, Hanan Khalil, &

Deborah Parker 2015. The Joanna Briggs Institute reviewers' manual 2015: methodology for JBI scoping reviews.

Petricoin III, Emanuel F., Ali M. Ardekani, Ben A. Hitt, Peter J. Levine, Vincent A. Fusaro, Seth M. Steinberg, Gordon B. Mills et al 2002. Use of proteomic patterns in serum to identify ovarian cancer. The lancet, 359(9306), pp.572-577

Radhakrishnan, Kurupath 2009. Challenges in the management of epilepsy in resource-poor countries. Nature Reviews Neurology, 5(6), p.323.

Raghupathi, Wullianallur 2016. Data mining in healthcare. Healthcare Informatics:

Improving Efficiency through Technology, Analytics, and Management, pp.353-372.

62

Raghupathi, Wullianallur, & Viju Raghupathi 2014. Big data analytics in healthcare:

promise and potential. Health information science and systems, 2(1), p.3.

Richards, Graeme, Victor J. Rayward-Smith, P. H. Sönksen, S. Carey, & C. Weng 2001.

Data mining for indicators of early mortality in a database of clinical records. Artificial intelligence in medicine, 22(3), pp.215-231.

Rijo, Rui, Catarina Silva, Luis Pereira, Dulce Gonçalves, & Margarida Agostinho 2014 .Decision support system to diagnosis and classification of epilepsy in children’, Journal of Universal Computer Science, 20(6), pp. 907–923.

Sadati, Nasser, Hamid Reza Mohseni, & Arash Maghsoudi 2006. Epileptic seizure detection using neural fuzzy networks. In Fuzzy Systems, 2006 IEEE International Conference on (pp. 596-600). IEEE.

Sander, J. W., & S. D. Shorvon 1996. Epidemiology of the epilepsies. Journal of neurology, neurosurgery, and psychiatry, 61(5), p.433.

Sanei, Saeid, & J. A. Chambers 2007. Fundamentals of EEG signal processing. EEG Signal Processing, pp.35-125.

Schuyler, Ronald, Andrew White, Kevin Staley, & Krzysztof J. Cios 2007. Epileptic seizure detection. IEEE Engineering in medicine and Biology Magazine, 26(2), p.74.

Scott, Robert A., Samden D. Lhatoo, & Josemir WAS Sander 2001. The treatment of epilepsy in developing countries: where do we go from here?. Bulletin of the World Health Organization, 79, pp.344-351.

Senanayake, Nimal, & Gustavo C. Román 1993. Epidemiology of epilepsy in developing countries. Bulletin of the world health organization, 71(2), p.247.

Seng, Cher Hau, Ramazan Demirli, Lunal Khuon, & Donovan Bolger 2012. Seizure detection in EEG signals using support vector machines. In Bioengineering Conference (NEBEC), 2012 38th Annual Northeast (pp. 231-232). IEEE.

63

Shah, Baiju R., & Lorraine L. Lipscombe 2015. Clinical diabetes research using data mining: a Canadian perspective. Canadian journal of diabetes, 39(3), pp.235-238.

Sharma, Seema, Jitendra Agrawal, Shikha Agarwal, & Sanjeev Sharma 2013.Machine learning techniques for data mining: A survey’, in 2013 IEEE International Conference on Computational Intelligence and Computing Research. doi:

10.1109/ICCIC.2013.6724149.

Siddiqui, Mohammad Khubeb, and Md Zahidul Islam 2016, November. Data mining approach in seizure detection. In Region 10 Conference (TENCON), 2016 IEEE (pp.

3579-3583). IEEE.

Sierra, Basilio, & Pedro Larranaga 1998. Predicting survival in malignant skin melanoma using Bayesian networks automatically induced by genetic algorithms. An empirical comparison between different approaches. Artificial Intelligence in Medicine, 14(1-2), pp.215-230.

Silver, Michael, Taiki Sakata, Hua-Ching Su, Charles Herman, Steven B. Dolins, &

Michael J. O Shea 2001. Case study: how to apply data mining techniques in a healthcare data warehouse. Journal of healthcare information management, 15(2), pp.155-164.

Stafstrom, Carl E., & Lionel Carmant 2015. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harbor perspectives in medicine, 5(6), p.a022426.

Staley, Kevin J., & F. Edward Dudek 2006. Interictal Spikes and Epileptogenesis.

Epilepsy Currents. doi: 10.1111/j.1535-7511.2006.00145.x.

Stel, Vianda S., Saskia MF Pluijm, Dorly JH Deeg, Johannes H. Smit, Lex M. Bouter, &

Paul Lips. 2003. A Classification Tree for Predicting Recurrent Falling in Community‐

Dwelling Older Persons. Journal of the American Geriatrics Society, 51(10), pp.1356-1364.

Thakor, Nitish V., & Shanbao Tong 2004. Advances in quantitative electroencephalogram analysis methods. Annu. Rev. Biomed. Eng., 6, pp.453-495.

64

Tomson, Torbjörn, Lina Nashef, & Philippe Ryvlin 2008. Sudden unexpected death in epilepsy: current knowledge and future directions. The Lancet Neurology, 7(11), pp.1021-1031.

Turner, J. T., Adam Page, Tinoosh Mohsenin, & Tim Oates 2014. Deep Belief Networks used on High Resolution Multichannel Electroencephalography Data for Seizure Detection’.

Tzallas, Alexandros T., Markos G. Tsipouras, & Dimitrios I. Fotiadis 2009. Epileptic seizure detection in EEGs using time-frequency analysis.’, IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society, 13(5), pp. 703–710. doi: 10.1109/TITB.2009.2017939.

Tzallas, Alexandros T., Markos G. Tsipouras, Dimitrios G. Tsalikakis, Evaggelos C.

Karvounis, Loukas Astrakas, Spiros Konitsiotis, & Margaret Tzaphlidou 2012.

Automated epileptic seizure detection methods: a review study. In Epilepsy-histological, electroencephalographic and psychological aspects. InTech.

Übeyli, Elif Derya 2010. Least squares support vector machine employing model-based methods coefficients for analysis of EEG signals. Expert Systems with Applications, 37(1), pp.233-239.

Valenti, Pablo, Enrique Cazamajou, Marcelo Scarpettini, Ariel Aizemberg, Walter Silva,

& Silvia Kochen 2006. Automatic detection of interictal spikes using data mining models’, Journal of Neuroscience Methods, 150(1), pp. 105–110. doi:

10.1016/j.jneumeth.2005.06.005.

Wahab, Abdul 2010. Difficulties in treatment and management of epilepsy and challenges in new drug development. Pharmaceuticals, 3(7), pp.2090-2110..

Wang, Qiong, George M. Garrity, James M. Tiedje, & James R. Cole 2007. Naïve Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial

65

taxonomy’, Applied and Environmental Microbiology. doi: 10.1128/AEM.00062-07.

Wang, Xue-qing, & Shu-qin Zhang 2009. Research on efficient coverage problem of node in wireless sensor networks. In Industrial Mechatronics and Automation, 2009. ICIMA 2009. International Conference on (pp. 9-13). IEEE.

Wang, Fenglin, Qingfang Meng, & Yuehui Chen 2014 July. The neoteric feature extraction method of epilepsy EEG based on the vertex strength distribution of weighted complex network. In Neural Networks (IJCNN), 2014 International Joint Conference on (pp. 3234-3239). IEEE.

Wang, Shouyi, Wanpracha Art Chaovalitwongse, & Stephen Wong 2014. A gradient-based adaptive learning framework for online seisure prediction. International journal of data mining and bioinformatics, 10(1), pp.49-64.

World Health organization

http://www.who.int/mediacentre/factsheets/fs999/en/ accessed 16.4.2018 World Health Organization: Geneva, Switzerland, pp.6-9.

Yildirim, Pinar, Ljiljana Majnarić, Ozgur Ilyas Ekmekci, & Andreas Holzinger 2014.

Knowledge discovery of drug data on the example of adverse reaction prediction. BMC bioinformatics, 15(6), p.S7

Yoo, Ill-Hoi, & Min Song 2008. Biomedical ontologies and text mining for biomedicine and healthcare: A survey. Journal of Computing Science and Engineering, 2(2), pp.109-136.

Yoo, Illhoi, Patricia Alafaireet, Miroslav Marinov, Keila Pena-Hernandez, Rajitha Gopidi, Jia-Fu Chang, and Lei Hua 2012. Data mining in healthcare and biomedicine: a survey of the literature. Journal of medical systems, 36(4), pp.2431-2448.

Yu, J. S., Stefano Ongarello, R. Fiedler, X. W. Chen, Gianna Toffolo, Claudio Cobelli,

& Zlatko Trajanosk 2005. Ovarian cancer identification based on dimensionality

66

reduction for high-throughput mass spectrometry data. Bioinformatics, 21(10), pp.2200-2209

Zainuddin, Zarita, Lai Kee Huong, & Ong Pauline 2013. Reliable epileptic seizure detection using an improved wavelet neural network’, Australasian Medical Journal, 6(5), pp. 308–314. doi: 10.4066/AMJ.2013.1640.

Zikopoulos, Paul, & Chris Eaton 2011. Understanding big data: Analytics for enterprise class hadoop and streaming data. McGraw-Hill Osborne Media.

67 APPENDICES

APPENDIX A: Data extraction table

Author,

Study aim Study topic Data source Applied Data

mining method

Method of feature extraction

Results Conclusion and comments affects the number of false positives.

Speed - Fast and can detect spikes in real time applied to EEG analysis for epilepsy seizure detection

Open-access data set from the University of Bonn, Epilepsy centre of the university hospital of Freiburg &

Hospital regional

Support vector machine & Bag of words

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across the 3 datasets.

Interpretability- not

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Public dataset from the University of Bonn Epilepsy centre (andrzejak et al 2001)

Classification The rule sets gotten by RF can be used as additional information for clinicians in the diagnosis of epilepsy

Classification The rule sets gotten by RF can be used as additional information for clinicians in the diagnosis of epilepsy