In this thesis, the current state-of-the-art MPI reconstruction and compensation methods were studied and further optimised. A special focus was on approaches which could reduce the scanning time. The possible interference of different compensation methods was evaluated and new approaches to avoid the artefacts generated by the compensation methods were devised.
The main observations of this thesis can be summarised as follows:
Half-time MPI with attenuation and MC-based scatter correction produced images of superior quality when compared to full time imaging with standard reconstruction. One hundred thousand simulated photons in the MC-based scatter correction did not add noise to the reconstructed images even with half scanning time, but provided a good quality correction.
Two scatter update iterations and 105 simulated photons for the 99mTc and 201Tl reconstructions and 106 simulated down-scatter photons were sufficient to obtain good quality images in the dual 99mTc/201Tl reconstruction. In order to fully compensate for the down-scatter effect in the reconstructed images, lead X-ray emissions need to be taken into account.
The traditional reconstruction-reprojection-based motion compensation method, with three update iterations and mutual information cost function, is a good option for rapid motion correction in clinical myocardial perfusion SPECT.
All the three Bayesian reconstruction methods studied reduced the collimator correction artefacts.
The Bowsher prior achieved a reduction without
72
evoking adverse effects on reconstructed resolution or on the contrast.
The MPI technique can benefit greatly by incorporation of modern correction algorithms.
73
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Publications of the University of Eastern Finland Dissertations in Forestry and Natural Sciences
Publications of the University of Eastern Finland Dissertations in Forestry and Natural Sciences
isbn 978-952-61-1505-4
Tuija Kangasmaa
Evaluation and Optimization
of Novel Reconstruction Methods for Myocardial Perfusion SPECT
Myocardial perfusion imaging (MPI) is one of the most common types of SPECT studies, being highly valued for its diagnostic accuracy. However, image noise, photon attenuation, Compton scatter, collimator-detector response (CDR) and patient motion hamper the image quality of MPI. These image degrading factors have been investigated widely and the modern reconstruction-based compensation methods can greatly improve the image quality. Recently CDR compensation has attracted considerable interest, because it allows diagnostically satisfying images to be acquired in half of the acquisition time currently in use.
Shorter scan times both reduce artifacts related to patient motion and increase the patient throughput. The aim of this thesis was to validate and optimize novel SPECT reconstruction and compensation techniques for use with MPI. The specific focus was on scan time reduction and on CDR compensation.
dissertations | 142 | Tuija Kangasmaa | Evaluation and Optimization of Novel Reconstruction Methods for Myocardial Perfusion SPECT
dissertations | 142 | Tuija Kangasmaa | Evaluation and Optimization of Novel Reconstruction Methods for Myocardial Perfusion SPECT