Conclusion

This study identified the qualitative literature on Alzheimer's disease and the aerobic exercise relationship. The literature review result also identified what kinds of exercise are suitable for the elderly residents with AD. the research shows that after about 26- weeks of aerobic exercise training, older adults' memory biomarker, myokine Cathepsin B (CTSB), increased.

CTSB is a lysosomal enzyme secreted from muscle, enters circulation after exercise. CTSB relates to memory function and adult hippocampal neurogenesis. Older peoples with cognitive impairment have lower serum and cerebellum CTSB levels. "The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer's disease," said van Praag. (ANI，

2021)

The findings of this literature review led to the following conclusions:

1）Keep the planned and regularly Aerobic exercise for Alzheimer’s diseases, evidence presents the Aerobic exercise can help delay patients’ dementia degenerate.

2）Aerobic exercise promotes health status, decreases depression, and increases life satisfaction by preventing and delaying dementia and balancing growth.

21 3）Maintain long-term mild and routine exercise, stat at any age, we could delay the aging progress of our brain.

So far, the medical profession has not found a way to stop the memory and cognition losing of Alzheimer’s.

As The World Health Organization wards that dementia challenges, the number of dementias is growing to 78 million by 2030 and 139 million by 2050. Furthermore, the cost because of dementia is estimated to be US$ 1.3 trillion in 2019; this cost will be increased to US$ 1.7 trillion by 2030. (WHO,2021)

However, the lack of caregivers is a critical and acute problem currently. sufficient caregivers Prerequisites to solve this problem.

22 List of Abbreviations and acronyms

WHO-World Health Organization AD-Alzheimer's disease

OSF-Official statistics of Finland

ACE-Angiotensin-converting enzyme inhibitors EBM Guidelines-Evidence-Based Medicine Guidelines NIH-National Institute of Health

NIA-National Institute on Aging GMV-grey matter volume

HPC-The Higher Population Council ACHE-acetylcholinesterase inhibitors CST-Cognitive Stimulation Therapy SSE-square stepping exercise

23 Figures and Tables

Figure 1. The basic and task steps of humanet exercise. (mdpi.ijerph.18157848)

Figure 2. The composition of cognitive/exercise dual-task program. (mdpi.ijerph.18157848) Table 1: Research data table

Table 2: Database search results

Table 3: Analysis of the Data included in table Table 4: The caregiver's work schedule

24 References

Electronic reference

Aerobic exercise. (n.d.) Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. (2003). Retrieved November 10, 2021, from https://medical-dictionary.thefreedictionary.com/aerobic+exercise

Aerobic exercise helps cognitive function in older adults, finds study. Asian News

International. Jun 19, 2021. Available from: https://www.proquest.com/newspapers/aerobic-exercise-helps-cognitive-function-older/docview/2542629373/se-2?accountid=12003 Alzheimer’s disease, Anne Remes and Merja Hallikainen, EBM Guidelines, 17.1. 2020 updated.

Availabe from https://www-terveysportti-fi.nelli.laurea.fi/dtk/ebmg/koti

Chen L, Chao F, Lu W, et al. Long-term running exercise delays age-related changes in white matter in rats. Frontiers in Aging Neuroscience. 2020. https://www.proquest.com/scholarly-journals/long-term-running-exercise-delays-age-related/docview/2453828774/se-2. doi:

http://dx.doi.org/10.3389/fnagi.2020.590530

Evidence-based on medicines guidelines, Editors, 20.8.2015, Evidence summaries, Aerobic exercise to improve cognitive function in older people without known cognitive impairment, https://www.terveysportti.fi/dtk/ebmg/koti

Expert: Finland needs 30k more healthcare workers by 2030 .... https://yle.fi/news/3-11782213

Higher population council urges revising 'elderly' definition. Petra Jordan News Agency.

Amman, Sep 30, 2021. Available from:

https://www.proquest.com/docview/2577871872?accountid=12003

Merja Hallikainen & Teemu Paajanen，Sptember,8,2021, Muistioireet, lievä tiedonkäsittelyn heikentymä ja dementia, Accessed 11, November,2021,

https://www.terveysportti.fi/apps/dtk/ltk/article/ykt00879/search/Demen tia

NIH National Institute on Aging (NIA), Editors, July 08, 2021, Alzheimer's Disease Fact Sheet，

accessed 4, November,2021，https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet Narayanasamy SS, Vimalan V, Padmanabhan P, Gulyás B. An overview on cognitive function enhancement through physical exercises. Brain Sciences. 2021;11(10):1289.

https://www.proquest.com/scholarly-journals/overview-on-cognitive-function-enhancement/docview/2584310925/se-2. doi: http://dx.doi.org/10.3390/brainsci11101289 NIH National Institute on Aging (NIA)，July 08, 2021，BASICS OF ALZHEIMER’S DISEASE AND DEMENTIA， Accessed 4，November，2021， https://www.nia.nih.gov/health/what-alzheimers-disease

NIH National Institute on Aging (NIA) n.d, What Is Alzheimer’s Disease, accessed 4, November 2021, https://www.nia.nih.gov/health/what-alzheimers-disease

25 NHS,n.d, Treatment Alzheimer's disease, accessed November 8, 2021, Page last reviewed: 05 July 2021 Next review due: 05 July 2024

https://www.nhs.uk/conditions/alzheimers-disease/treatment/

Official Statistics of Finland (OSF): Causes of death [e-publication]. ISSN=1799-5078. 2019, Appendix table 1a. Deaths by underlying cause of death and by age in 2019, both sexes.

Helsinki: Statistics Finland [referred: 7.11.2021]. Access method:

http://www.stat.fi/til/ksyyt/2019/ksyyt_2019_2020-12-14_tau_001_en.html

Obisesan TO, Gillum RF, Johnson S, et al. Neuroprotection and neurodegeneration in alzheimer's disease: Role of cardiovascular disease risk factors, implications for dementia rates, and prevention with aerobic exercise in african americans. International Journal of Alzheimer's Disease. 2012;2012.

https://www.proquest.com/scholarly-journals/neuroprotection-neurodegeneration-alzheimers/docview/1347348346/se-2. doi:

http://dx.doi.org/10.1155/2012/568382.

Sok S, Shin E, Kim S, Kim M. Effects of Cognitive/Exercise dual-task program on the cognitive function, health status, depression, and life satisfaction of the elderly living in the

community. International Journal of Environmental Research and Public Health.

2021;18(15):7848. https://www.proquest.com/scholarly-journals/effects-cognitive-exercise-dual-task-program-on/docview/2558804586/se-2. doi:

http://dx.doi.org/10.3390/ijerph18157848.

Mayoclinic，21,Jun,2021, Alzheimer's disease, accessed 4, November, 2021, 7

https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447

Tao J, Liu J, Liu W, et al. Tai chi chuan and baduanjin increase grey matter volume in older adults: A brain imaging study. J Alzheimer's Dis. 2017;60(2):389-400.

https://www.proquest.com/scholarly-journals/tai-chi-chuan-baduanjin-increase-grey-matter/docview/1993988499/se-2. doi: http://dx.doi.org/10.3233/JAD-170477.

WHO, news, World failing to address dementia challenge; September 2.2021,

https://www.who.int/news/item/02-09-2021-world-failing-to-address-dementia-challenge Non-electronic references

Alzheimers disease, Medical book Duodecim, neurologist Kati Juva;10.8.2021;Article ID:

dlk00699 (026.032);© 2021 Kustannus Oy Duodecim

Author: the agency; Publisher: People's Sports Publishing House; 2009-09-30; Books ISBN: 978-7-5009-2586-6

Parle M, Vasudevan M, Singh N. Swim every day to keep dementia away. J Sports Sci Med.

2005;4(1):37-46. Published 2005 Mar 1.